218753 Caspase-5 Inhibitor I

218753
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₇H₄₂FN₇O₁₀

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
218753-1MG
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      Plastic ampoule 1 mg
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      218753-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
          Catalogue Number218753
          Brand Family Calbiochem®
          SynonymsZ-WE(OMe)HD(OMe)-FMK
          References
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Rano, T., et al. 1997. Chem. Biol. 4, 149.
          Product Information
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₇H₄₂FN₇O₁₀
          Chemical formulaC₃₇H₄₂FN₇O₁₀
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcaspase-1, caspase-4, caspase-5, caspase-8
          Puritysingle spot by TLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-5 Inhibitor I SDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-5 Inhibitor I Certificates of Analysis

          TitleLot Number
          218753

          References

          Reference overview
          Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Rano, T., et al. 1997. Chem. Biol. 4, 149.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-June-2008 JSW
          SynonymsZ-WE(OMe)HD(OMe)-FMK
          DescriptionA potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
          FormWhite solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₃₇H₄₂FN₇O₁₀
          Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
          Puritysingle spot by TLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
          Toxicity Standard Handling
          ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Rano, T., et al. 1997. Chem. Biol. 4, 149.