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264151 Caspase-3 Substrate VII, Fluorogenic - Calbiochem

264151
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Overview

Replacement Information

Key Specifications Table

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Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
264151-1MG
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      264151-5MG
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      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
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          Plastic ampoule 5 mg
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          Description
          OverviewFluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
          Catalogue Number264151
          Brand Family Calbiochem®
          SynonymsAc-DEVD-AFC
          References
          ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₃₀H₃₄F₃N₅O₁₃
          Chemical formulaC₃₀H₃₄F₃N₅O₁₃
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetFluorogenic caspase-3 substrate
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-3 Substrate VII, Fluorogenic - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-3 Substrate VII, Fluorogenic - Calbiochem Certificates of Analysis

          TitleLot Number
          264151

          References

          Reference overview
          Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

          Citations

          Title
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2008 RFH
          SynonymsAc-DEVD-AFC
          DescriptionFluorogenic caspase-3 substrate (excitation maximum: ~400 nm; emission maximum: ~505 nm). Also acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10.
          FormWhite lyophilized solid
          Chemical formulaC₃₀H₃₄F₃N₅O₁₃
          Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Citation
        • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.