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504713 CPCCOEt - CAS 179067-99-3 - Calbiochem

CPCCOEt - CAS 179067-99-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt

Primary Target: mGlu₁ receptors
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      179067-99-3C₁₃H₁₃NO₄
      Description
      OverviewA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
      Catalogue Number504713
      Brand Family Calbiochem®
      Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
      References
      ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
      Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
      Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
      Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
      Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
      Product Information
      CAS number179067-99-3
      FormWhite powder
      Hill FormulaC₁₃H₁₃NO₄
      Chemical formulaC₁₃H₁₃NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₁ receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CPCCOEt - CAS 179067-99-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Luongo L, et al. 2013. Neuropharmacol. 66, 317.
      Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
      Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
      Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
      Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms(E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu₁ Antagonist, CPCCOEt
      DescriptionA potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
      FormWhite powder
      CAS number179067-99-3
      Chemical formulaC₁₃H₁₃NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLuongo L, et al. 2013. Neuropharmacol. 66, 317.
      Jin, Y., et al. 2012. Pain Res. Treat. 2012, 915706.
      Tappe-Theodor, A., 2011. Mol Pain. 7, 38.
      Litschig, S., et al. 1999. Mol. Pharmacol. 55, 453.
      Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett. 6, 763.