219670 CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

219670
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₀F₃NO₃S₂ 307510-92-5

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219670-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674).
      Catalogue Number219670
      Brand Family Calbiochem®
      Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
      References
      ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
      Product Information
      CAS number307510-92-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₁₀F₃NO₃S₂
      Chemical formulaC₁₈H₁₀F₃NO₃S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCFTR
      Primary Target K<sub>i</sub>~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      219670

      References

      Reference overview
      Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
      DescriptionA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number307510-92-5
      Chemical formulaC₁₈H₁₀F₃NO₃S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
      Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
      Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.