In the opinion of most experts in the field of transfusion science the ideal anti-D for typing patients is one that does not react with D category VI cells. Millipore’s four IgM Anti-D antibodies do not detect these DVI cells and are therefore good candidates for use in formulating anti-D reagents for patient testing.
For typing donor blood, detection of D category VI red cells is required. FFMU KK, IgG anti-D made from clone MS-26, reacts with these cells and can be blended with any of the Millipore IgM FFMUs to create a product that detects all D, weak D and partial D phenotypes.
The results of the fine specificity of the Millipore monoclonal Anti-D antibodies are shown in the table below. These results are taken from the proceedings of the Third International Workshop on Red Cell and Related Antigens in Nantes 1996 and from original studies made by the clone creators.