197226 BCRP Inhbitor - Calbiochem

197226
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₂H₁₉N₃O₅

Pricing & Availability

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197226-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
      Catalogue Number197226
      Brand Family Calbiochem®
      SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
      References
      ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
      Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₂H₁₉N₃O₅
      Chemical formulaC₂₂H₁₉N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      BCRP Inhbitor - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      BCRP Inhbitor - Calbiochem Certificates of Analysis

      TitleLot Number
      197226

      References

      Reference overview
      Pick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
      Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
      DescriptionA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₉N₃O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
      Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.