616399 Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Kallikrein Inactivator

Primary Target: chymotrypsin
616399
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Overview

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Key Specifications Table

CAS #
9087-70-1

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      616399-500KU
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          Description
          Overview

          This product has been discontinued.



          Competitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
          Note: 1 KU = 1000 K.I.U.
          Catalogue Number616399
          Brand Family Calbiochem®
          SynonymsKallikrein Inactivator
          References
          ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
          Product Information
          CAS number9087-70-1
          Activity≥6500 KIU/ml
          Unit of DefinitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
          ATP CompetitiveN
          FormLiquid
          FormulationIn isotonic NaCl, aseptically filled.
          PI10.5
          ReversibleY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetchymotrypsin
          Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSYN5080000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          616399

          References

          Reference overview
          Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2010 JSW
          SynonymsKallikrein Inactivator
          DescriptionCompetitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
          FormLiquid
          FormulationIn isotonic NaCl, aseptically filled.
          CAS number9087-70-1
          RTECSYN5080000
          Activity≥6500 KIU/ml
          Unit definitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          Merck USA index14, 757
          ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
          Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
          Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.