508774 Apoptosis Activator VIII, TP421 - Calbiochem

508774
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₄H₃₅NO₂P+Br-.H₂O

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable triphenylphosphonium compound that exhibits selective toxicity towards cancer cells and inhibits their proliferation (IC50 = 400, 500, 800 nM and 1.1. µM for HPAC, MIA PaCa-2, BxPC-3, and PANC-1 pancreatic cancer cells, respectively). Arrests cell cycle at G0/G1 phase of the cell cycle in a time- and dose-dependent manner. It accumulates in mitochondria and induces mitochondrial and cytosolic accumulation of reactive oxygen species. Induces apoptosis by activating caspase-8 and 7 and by lowering the levels of Bcl-2 and survivin in cancer cells. Reduces autophagy as evidenced by a reduction in beclin-1 and increase in LC3B-II and p62 levels (at ~20 µM). Also shown to diminish Src phosphorylation (Tyr416) correspondingly reduce in Ser576 and Tyr861 phosphorylation in focal adhesion kinase (FAK).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508774
      Brand Family Calbiochem®
      Synonyms(2-(7-(Diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)triphenylphosphonium Salt
      References
      ReferencesMillard, M., et al. 2013. PLos One. 5, e13131.
      Product Information
      FormYellow powder
      Hill FormulaC₃₄H₃₅NO₂P+Br-.H₂O
      Chemical formulaC₃₄H₃₅NO₂P+Br-.H₂O
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>400 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Apoptosis Activator VIII, TP421 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Millard, M., et al. 2013. PLos One. 5, e13131.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      Synonyms(2-(7-(Diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)triphenylphosphonium Salt
      DescriptionA cell-permeable triphenylphosphonium compound that exhibits selective toxicity towards cancer cells and inhibits their proliferation (IC50 = 400, 500, 800 nM and 1.1. µM for HPAC, MIA PaCa-2, BxPC-3, and PANC-1 pancreatic cancer cells, respectively). Arrests cell cycle at G0/G1 phase of the cell cycle in a time- and dose-dependent manner. It accumulates in mitochondria and induces mitochondrial and cytosolic accumulation of reactive oxygen species. Induces apoptosis by activating caspase-8 and 7 and by lowering the levels of Bcl-2 and survivin in cancer cells. Reduces autophagy as evidenced by a reduction in beclin-1 and increase in LC3B-II and p62 levels (at ~20 µM). Also shown to diminish Src phosphorylation (Tyr416) correspondingly reduce in Ser576 and Tyr861 phosphorylation in focal adhesion kinase (FAK).
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₄H₃₅NO₂P+Br-.H₂O
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMillard, M., et al. 2013. PLos One. 5, e13131.