178273 Aphidicolin - CAS 38966-21-1 - Calbiochem

178273
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₀H₃₄O₄ 38966-21-1

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178273-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Also available as a 30 mM solution in DMSO (Cat. No. 504744).
      Catalogue Number178273
      Brand Family Calbiochem®
      References
      ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
      Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
      Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
      Hubermann, J.A. 1981. Cell 23, 647.
      Product Information
      CAS number38966-21-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₃₄O₄
      Chemical formulaC₂₀H₃₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA polymerase α, DNA polymerase δ
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSPB9185000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aphidicolin - CAS 38966-21-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aphidicolin - CAS 38966-21-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      178273

      References

      Reference overview
      Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
      Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
      Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
      Hubermann, J.A. 1981. Cell 23, 647.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
      FormWhite solid
      CAS number38966-21-1
      RTECSPB9185000
      Chemical formulaC₂₀H₃₄O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (50 mg/ml), Ethanol, or Methanol
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 727
      ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
      Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311.
      Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909.
      Hubermann, J.A. 1981. Cell 23, 647.