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MAB329 Anti-Synaptophysin Antibody, clone SP15

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MAB329
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ht, Po, RELISA, WB, IH(P)MAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB329
      Replaces04-1019
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Synaptophysin Antibody, clone SP15
      Alternate Names
      • Major Synaptic Vesicle Protein p38
      References
      Product Information
      FormatAscites
      HS Code3002 15 90
      PresentationLiquid
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Synaptophysin Antibody, clone SP15 is validated for use in ELISA, WB, IH(P) for the detection of Synaptophysin.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry at 1:200-1:5,000.

      Formalin fixed (fixed <4 weeks), paraffin embedded

      Frozen

      4% Paraformaldehyde

      Western blotting at 1:2,500-1:10,000.

      ELISA at 1:500

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenCrude synaptic immunoprecipitate (Human)
      CloneSP15
      HostMouse
      SpecificitySynaptophysin. Reacts with synaptophysin expressed in CHO cells.
      IsotypeIgM
      Species Reactivity
      • Human
      • Hamster
      • Pig
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySynaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM]
      Gene Symbol
      • SYP
      • synaptophysin
      • Synaptophysin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08247 # Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.
      SIZE: 313 amino acids; 33845 Da
      SUBUNIT: Homohexamer or homotetramer.
      SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
      DOMAIN: SwissProt: P08247 The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
      PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).
      SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      MAB329 04053252662188

      Documentation

      Anti-Synaptophysin Antibody, clone SP15 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Synaptophysin Antibody, clone SP15 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-SYNAPTOPHYSIN MONOCLONAL ANTIBODY - 2395767 2395767
      MOUSE ANTI-SYNAPTOPHYSIN - 3217085 3217085
      MOUSE ANTI-SYNAPTOPHYSIN - 3379366 3379366
      MOUSE ANTI-SYNAPTOPHYSIN - 3460345 3460345
      MOUSE ANTI-SYNAPTOPHYSIN - 3464124 3464124
      MOUSE ANTI-SYNAPTOPHYSIN - 3466635 3466635
      MOUSE ANTI-SYNAPTOPHYSIN - 3470155 3470155
      MOUSE ANTI-SYNAPTOPHYSIN - 3473511 3473511
      MOUSE ANTI-SYNAPTOPHYSIN - 3474163 3474163
      MOUSE ANTI-SYNAPTOPHYSIN - 3482029 3482029

      References

      Reference overviewApplicationSpeciesPub Med ID
      Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats.
      Deng, X; Li, M; Ai, W; He, L; Lu, D; Patrylo, PR; Cai, H; Luo, X; Li, Z; Yan, X
      Advances in Alzheimer's disease  3  78-93  2014

      Show Abstract
      25360394 25360394
      Amyloid plaque pathogenesis in 5XFAD mouse spinal cord: retrograde transneuronal modulation after peripheral nerve injury.
      Li, JM; Xue, ZQ; Deng, SH; Luo, XG; Patrylo, PR; Rose, GW; Cai, H; Cai, Y; Yan, XX
      Neurotoxicity research  24  1-14  2013

      Show Abstract
      23055086 23055086
      Lidocaine attenuates cognitive impairment after isoflurane anesthesia in old rats.
      Lin, D; Cao, L; Wang, Z; Li, J; Washington, JM; Zuo, Z
      Behavioural brain research  228  319-27  2012

      Show Abstract
      22192381 22192381
      BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology.
      Cai, Y; Zhang, XM; Macklin, LN; Cai, H; Luo, XG; Oddo, S; Laferla, FM; Struble, RG; Rose, GM; Patrylo, PR; Yan, XX
      Neurotoxicity research  21  160-74  2012

      Show Abstract
      ImmunohistochemistryMouse21725719 21725719
      β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation.
      Cai, Y; Xiong, K; Zhang, XM; Cai, H; Luo, XG; Feng, JC; Clough, RW; Struble, RG; Patrylo, PR; Chu, Y; Kordower, JH; Yan, XX
      The European journal of neuroscience  32  1223-38  2010

      Show Abstract Full Text Article
      Immunohistochemistry20726888 20726888
      Functional deprivation promotes amyloid plaque pathogenesis in Tg2576 mouse olfactory bulb and piriform cortex.
      Zhang, XM; Xiong, K; Cai, Y; Cai, H; Luo, XG; Feng, JC; Clough, RW; Patrylo, PR; Struble, RG; Yan, XX
      The European journal of neuroscience  31  710-21  2010

      Show Abstract Full Text Article
      ImmunohistochemistryMouse20384814 20384814
      Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.
      Xue-Mei Zhang,Yan Cai,Kun Xiong,Huaibin Cai,Xue-Gang Luo,Jia-Chun Feng,Richard W Clough,Robert G Struble,Peter R Patrylo,Xiao-Xin Yan
      The European journal of neuroscience  30  2009

      Show Abstract Full Text Article
      20092570 20092570
      Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neurons.
      Shim, SY; Wang, J; Asada, N; Neumayer, G; Tran, HC; Ishiguro, K; Sanada, K; Nakatani, Y; Nguyen, MD
      The Journal of neuroscience : the official journal of the Society for Neuroscience  28  3604-14  2008

      Show Abstract
      18385319 18385319
      Postnatal development of the primate hippocampal formation.
      Lavenex, P; Banta Lavenex, P; Amaral, DG
      Developmental neuroscience  29  179-92  2007

      Show Abstract
      17148960 17148960
      Orphan glutamate receptor delta1 subunit required for high-frequency hearing.
      Gao, J; Maison, SF; Wu, X; Hirose, K; Jones, SM; Bayazitov, I; Tian, Y; Mittleman, G; Matthews, DB; Zakharenko, SS; Liberman, MC; Zuo, J
      Molecular and cellular biology  27  4500-12  2007

      Show Abstract
      17438141 17438141

      Data Sheet

      Title
      MOUSE ANTI-SYNAPTOPHYSIN MONOCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies