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07-324 Anti-PP2A Antibody, C subunit

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      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Catalogue Number07-324
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PP2A Antibody, C subunit
      Product Information
      FormatAffinity Purified
      Presentation0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30%
      Quality LevelMQ100
      ApplicationThis Anti-PP2A Antibody, C subunit is validated for use in WB for the detection of PP2A.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 290-304 (DPAPRRGEPHVTRRT) of human PP2A
      SpecificityPP2A catalytic subunit
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
      Gene Symbol
      • PPP2CA
      • PP2CA
      • PP2A-alpha
      • RP-C
      • PP2Ac
      Purification MethodImmunoaffinity Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P67775 # PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Can dephosphorylate SV40 large T antigen and p53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen.
      COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).
      SIZE: 309 amino acids; 35594 Da
      SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
      PTM: Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly. It varies during the cell cycle. & Phosphorylation of either threonine (by autophosphorylation- activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
      SIMILARITY: SwissProt: P67775 ## Belongs to the PPP phosphatase family. PP-1 subfamily.
      Molecular Weight36kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from mouse brain, heart, testes and spleen homogenates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Global Trade Item Number
      Catalog Number GTIN
      07-324 04053252581946


      Anti-PP2A Antibody, C subunit SDS


      Safety Data Sheet (SDS) 

      Anti-PP2A Antibody, C subunit Certificates of Analysis

      TitleLot Number
      Anti-PP2A, C subunit (rabbit immunoaffinity purified IgG) - 2368743 2368743
      Anti-PP2A, C subunit (rabbit immunoaffinity purified IgG) 2914959
      Anti-PP2A, C subunit (rabbit immunoaffinity purified IgG) - 2231282 2231282
      Anti-PP2A, C subunit (rabbit immunoaffinity purified IgG) - 2982402 2982402
      Anti-PP2A, C subunit - 22281 22281
      Anti-PP2A, C subunit - 3211906 3211906
      Anti-PP2A, C subunit - 32477 32477
      Anti-PP2A, C subunit - 3407322 3407322
      Anti-PP2A, C subunit - 3995160 3995160
      Anti-PP2A, C subunit - 4001957 4001957


      Reference overviewApplicationPub Med ID
      Characterization of SET/I2PP2A isoforms in dogs.
      Yabe, R; Fujiwara, N; Mizuno, T; Usui, T; Ohama, T; Sato, K
      The Journal of veterinary medical science / the Japanese Society of Veterinary Science  76  1235-40  2014

      Show Abstract
      24897959 24897959
      NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink.
      Ulanovskaya, OA; Zuhl, AM; Cravatt, BF
      Nature chemical biology  9  300-6  2013

      Show Abstract
      Western Blotting23455543 23455543
      Phenylarsine oxide binding reveals redox-active and potential regulatory vicinal thiols on the catalytic subunit of protein phosphatase 2A.
      Foley TD, Melideo SL, Healey AE, Lucas EJ, Koval JA
      Neurochem Res  36  232-40. Epub 2010 Nov 16.  2011

      Show Abstract
      21080067 21080067