AB15134 Anti-Neurotensin Receptor 2 Antibody

AB15134
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB, IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB15134
      ReplacesAB9521
      DescriptionAnti-Neurotensin Receptor 2 Antibody
      Alternate Names
      • Levocabastine-sensitive neurotensin receptor
      • NTR2 receptor
      • neurotensin receptor 2
      • neurotensin receptor, type 2
      Background InformationNeurotensin Receptor 2 (NTR2) is a member of the G-protein coupled receptor family. Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents (Kinkead and Nemeroff, 2004). In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin (Castagliuolo et al., 1999). The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR2 recognizes a histamine H1 receptor antagonist that had been shown to compete with neurotensin for low-affinity binding sites in the brain.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human cortex lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of mouse brain lysate.

      Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of rat brain lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide from the extracellular domain of human Neurotensin Receptor 2.
      EpitopeExtracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Neurotensin Receptor 2.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteProven to react with human, mouse, and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq]
      Gene Symbol
      • NTSR2
      • NTR2
      • NT-R-2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.

      SIZE: 410 amino acids; 45413 Da

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
      Molecular Weight45.413 kDa is the calculated molecular weight. In Western Blot, immunoreactive bands which might reflect multimeric species of Neurotensin Receptor 2, are detected at approximately 60-65 kDa, 75 kDa, and 80-85 kDa. Sarret, P., et al. (2003). J Comp Neurol. 461(4):520-538.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human cortex lysate.

      Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of human cortex lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Neurotensin Receptor 2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neurotensin Receptor 2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Neurotensin Receptor 23072301
      Anti-Neurotensin Receptor 2 - 25658342565834
      Anti-Neurotensin Receptor 2 - NRG1663851NRG1663851
      Anti-Neurotensin Receptor 2 -25472012547201
      Anti-Neurotensin Receptor 2 -25563962556396
      Anti-Neurotensin Receptor 2 -27176522717652
      Anti-Neurotensin Receptor 2 Polyclonal Antibody2955691
      Anti-Neurotensin Receptor 2 Polyclonal Antibody2947639
      Anti-Neurotensin Receptor 2 Polyclonal Antibody2967233