ABN78C3 Anti-NeuN (rabbit) Antibody, Cy3 Conjugate

ABN78C3
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, M ICC Rb Cy3 Polyclonal Antibody
      Description
      Catalogue NumberABN78C3
      DescriptionAnti-NeuN (rabbit) Antibody, Cy3 Conjugate
      Alternate Names
      • NEUronal Nuclei
      • Neuronal Nuclei
      Background InformationABN78 is a rabbit polyclonal version of the Anti-NeuN, clone A60 (MAB377), NeuN is a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.
      References
      Product Information
      FormatCy3
      Control
      • Rat E18 cortex cells
      PresentationPurified rabbit polyclonal conjugated to Cy3 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NeuN (rabbit) Antibody, Cy3 Conjugate is an antibody against NeuN (rabbit) for use in IC.
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to mouse NeuN.
      EpitopeN-terminus
      HostRabbit
      SpecificityThis antibody recognizes NeuN at the N-terminus.
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteDemonstrated to react with Mouse and Rat. The unconjugated rabbit Anti-NeuN (Catalog No. ABN78) has been shown to work in human.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • NeuN
      Purification MethodAffinity Purfied
      Molecular WeightThe unconjugated parent antibody (Cat. No. ABN78) has an observed molecular weight at ~46/48 kDa. An uncharacterized band appears at ~62 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemistry in rat E18 cortex cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected NeuN in rat E18 cortex cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-NeuN (rabbit) Antibody, Cy3 Conjugate SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NeuN (rabbit) Antibody, Cy3 Conjugate Certificates of Analysis

      TitleLot Number
      Anti-NeuN (rabbit polyclonal), Cy3 -27182712718271
      Anti-NeuN (rabbit polyclonal), Cy3 -27500972750097
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate2901575
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate3109759
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate2982381
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate3075602
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate - 21282392128239
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate - 23883612388361
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate - 24615882461588
      Anti-NeuN (rabbit polyclonal), Cy3 Conjugate - 19839781983978