ABN78B Anti-NeuN (rabbit) Antibody, Biotin Conjugate

ABN78B
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M IHC Rb Biotin Polyclonal Antibody
      Description
      Catalogue NumberABN78B
      DescriptionAnti-NeuN (rabbit) Antibody, Biotin Conjugate
      Alternate Names
      • NEUronal Nuclei
      • Neuronal Nuclei
      Background InformationABN78 is a rabbit polyclonal version of the Anti-NeuN, clone A60 (MAB377), NeuN is a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.
      References
      Product Information
      FormatBiotin
      Control
      • Adult mouse brain tissue
      PresentationPurified rabbit polyclonal conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NeuN (rabbit) Antibody, Biotin Conjugate detects level of NeuN (rabbit) & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to mouse NeuN.
      EpitopeN-terminus
      HostRabbit
      SpecificityThis antibody recognizes NeuN at the N-terminus. The unconjugated version if this antibody (ABN78) has been shown to work in human and rat
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • NeuN
      Purification MethodAffinity Purfied
      Molecular WeightThe unconjugated parent antibody (Cat. No. ABN78) has an observed molecular weight at ~46/48 kDa. An uncharacterized band appears at ~62 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in adult mouse brain tissue.

      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected NeuN in adult mouse brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-NeuN (rabbit) Antibody, Biotin Conjugate SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NeuN (rabbit) Antibody, Biotin Conjugate Certificates of Analysis

      TitleLot Number
      Anti-NeuN (rabbit polyclonal), Biotin -28123062812306
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate2461566
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate3005309
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate2838458
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate - 20513992051399
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate - 32427163242716
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate - NRG1922534NRG1922534
      Anti-NeuN (rabbit polyclonal), Biotin Conjugate -26685102668510