MABN350 Anti-NTR1 Antibody, clone 8F11.1

MABN350
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M WB, IH(P) M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABN350
      DescriptionAnti-NTR1 Antibody, clone 8F11.1
      Alternate Names
      • Neurotensin receptor type 1
      • NT-R-1
      • NTR1
      • High-affinity levocabastine-insensitive neurotensin receptor
      • NTRH
      Background InformationNeurotensin receptor type 1 (UniProt P30989; also known as High-affinity levocabastine-insensitive neurotensin receptor, NT-R-1, NTR1, NTRH) is encoded by the NTSR1 (also known as NTRR) gene (Gene ID 4923) in human. Neurotensin (NT) is a tridecapeptide that acts as a neuromodulator in the CNS. It also behaves as a hormone in the gastrointestinal tract. Four different NTSRs have been reported. NTSR1 and NTSR2 are seven-transmembrane G-protein-coupled receptors (GPCRs), while NTSR3 and NTSR4 are members of the sortilin protein family with a single-transmembrane spanning domain. NTSR1 is a high affinity NT receptor and plays an important role in cancer cell proliferation, survival, mobility, and invasion. NT has also been implicated in the pathophysiology of several CNS disorders, such as schizophrenia, drug abuse, eating disorders, and Parkinson’s disease.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-NTR1 Antibody, clone 8F11.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of NTR1 .
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NTR1 in human thalamus and human frontal cortex tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NTR1 near the C-terminus.
      EpitopeNear C-terminus
      Clone8F11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NTSR1
      • NTRR
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~49 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse hypothalamus tissue lysate.

      Western Blotting Analysis: 2.5 µg/mL of this antibody detected NTR1 in 10 µg of mouse hypothalamus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications