437695 Anti-Lipoic Acid Rabbit pAb

437695
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Overview

Replacement Information

Key Specifications Table

Species ReactivityHostAntibody Type
A Broad Range Of Species Rb Polyclonal Antibody

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
437695-100UL
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      Plastic ampoule 100 ul
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      Description
      OverviewRecognizes native lipoic acid. Does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
      Catalogue Number437695
      Brand Family Calbiochem®
      SynonymsAnti-LA
      References
      ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
      Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
      Patrick. L. 2000. Altern. Med. Rev. 5, 290.
      Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
      Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.
      Product Information
      FormLiquid
      Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Paraffin Sections
      Enzyme-Linked Immunosorbent Assay
      Frozen Sections
      Immunoblotting (Western Blotting)
      Application NotesELISA (1:500-1:1000)
      Frozen Sections (1:50-1:500)
      Immunoblotting (1:1000-1:10,000)
      Paraffin Sections (1:50-1:500)
      Application CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogenlipoic acid conjugated to KLH
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • A Broad Range Of Species
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Lipoic Acid Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Lipoic Acid Rabbit pAb Certificates of Analysis

      TitleLot Number
      437695

      References

      Reference overview
      Sasaki, M., et al. 2000. J. Autoimmun. 15, 51.
      Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
      Patrick. L. 2000. Altern. Med. Rev. 5, 290.
      Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
      Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2007 RFH
      SynonymsAnti-LA
      ApplicationELISA (1:500-1:1000)
      Frozen Sections (1:50-1:500)
      Immunoblotting (1:1000-1:10,000)
      Paraffin Sections (1:50-1:500)
      DescriptionRabbit polyclonal antibody supplied as diluted serum. Recognizes native lipoic acid and lipoic acid covalently attached to proteins.
      BackgroundLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, α-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
      HostRabbit
      Immunogenlipoic acid conjugated to KLH
      IsotypeIgG
      Speciesa broad range of species
      FormLiquid
      Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
      PreservativeNone
      CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
      Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
      Patrick. L. 2000. Altern. Med. Rev. 5, 290.
      Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
      Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.