MAB5514 Anti-Choline Transporter Antibody, clone 62-2E8

MAB5514
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M ICC, IHC, WB M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB5514
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Transporter Antibody, clone 62-2E8
      Alternate Names
      • CHT
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect Choline Transporter using this Anti-Choline Transporter Antibody, clone 62-2E8 validated for use in IC, IH & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot. The antibody detects a 65 kDa band in mouse brain tissue lysate. The CHT immunoreactivity was most abundant in the striatum.

      Immunohistochemistry 1:2,000 - 1:8,000

      Immunocytochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from the C-terminus of human CHT.
      Clone62-2E8
      HostMouse
      SpecificityHemicholinium-3-sensitive choline transporter (CHT).
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholine is a direct precursor of acetylcholine (ACh), a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., 2000 [PubMed 11027560]).[supplied by OMIM]
      Gene Symbol
      • SLC5A7
      • MGC126299
      • MGC126300
      • CHT1
      • hCHT
      • CHT
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9GZV3 # Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent.
      SIZE: 580 amino acids; 63204 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in putamen, spinal cord and medulla. Specific for cholinergic neurons.
      PTM: Phosphorylated (By similarity).
      SIMILARITY: SwissProt: Q9GZV3 ## Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      MISCELLANEOUS: Specifically inhibited by nanomolar concentrations of hemicholinium 3.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Choline Transporter Antibody, clone 62-2E8 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Choline Transporter Antibody, clone 62-2E8 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) - 32451413245141
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) -27860832786083
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY3115118
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY3085043
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 21236482123648
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 21400202140020
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 23835422383542
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 24502102450210
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 20909262090926
      MOUSE ANTI-CHOLINE TRANSPORTER (CHT) MONOCLONAL ANTIBODY - 20953362095336

      References

      Reference overviewApplicationPub Med ID
      Oral haloperidol or risperidone treatment in rats: temporal effects on nerve growth factor receptors, cholinergic neurons, and memory performance.
      Terry, AV; Gearhart, DA; Warner, SE; Zhang, G; Bartlett, MG; Middlemore, ML; Beck, WD; Mahadik, SP; Waller, JL
      Neuroscience  146  1316-32  2007

      Show Abstract
      ELISA17434684 17434684

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies