AB5964 Anti-Choline Acetyltransferase Antibody

AB5964
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H IHC, WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5964
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Acetyltransferase Antibody
      Alternate Names
      • ChAT
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid.
      Applications
      ApplicationDetect Choline Acetyltransferase using this Anti-Choline Acetyltransferase Antibody validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunoblotting

      Immunohistochemistry: 1:200 using DAB with nickel enhancement. The antibody has been used successfully on 50μm human medulla sections which were blocked with 3% H2O2 for 30 min, blocked with 10% normal serum (donkey) for 30 min and citrate buffer (pH 3.0) retrieval for 30 min.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFusion protein
      HostRabbit
      SpecificityCholine Acetyltransferase, human. Does not appear to work on rat or mouse.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
      Gene Symbol
      • CHAT
      • ChAT
      • CMS1A2
      • CHOACTase
      • CMS1A
      • EC 2.3.1.6
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
      SIZE: 748 amino acids; 82568 Da
      DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
      SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

      During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Choline Acetyltransferase Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Choline Acetyltransferase Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE - 20382642038264
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE POLYCLONAL ANTIBODY - 23438212343821
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE POLYCLONAL ANTIBODY - 20559662055966

      References

      Reference overviewPub Med ID
      Retrovirally mediated telomerase immortalization of neural progenitor cells.
      Neeta S Roy,Devin Chandler-Militello,Gang Lu,Su Wang,Steven A Goldman
      Nature protocols  2  2007

      Show Abstract
      18007617 18007617

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies