AB5042 Anti-Choline Acetyltransferase Antibody

AB5042
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Av, Gp, R IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5042
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Choline Acetyltransferase Antibody
      Alternate Names
      • ChAT
      References
      Product Information
      FormatSerum
      PresentationLyophilized. Reconstitute with 100 μL of sterile distilled water. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect Choline Acetyltransferase using this Anti-Choline Acetyltransferase Antibody validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:2,000-1:4,000 in rat basal forebrain.

      Western blot

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 22 amino acid synthetic peptide from porcine ChAT, coupled to KLH. The peptide sequence is GLFSSYRLPGHTQDTLVAQKSS. Due to sequence similarity, the antibody is expected to react with pig, rat, mouse and human ChAT.
      HostRabbit
      SpecificityWill stain cholinergic neurons in rat central and peripheral nervous systems.
      Species Reactivity
      • Avian
      • Guinea Pig
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
      Gene Symbol
      • CHAT
      • ChAT
      • CMS1A2
      • CHOACTase
      • CMS1A
      • EC 2.3.1.6
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28329 # Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
      SIZE: 748 amino acids; 82568 Da
      DISEASE: SwissProt: P28329 # Defects in CHAT are the cause of familial infantile myasthenia gravis 2 (FIMG2) [MIM:254210, 254200]; also known as CMS-EA. FIMG2 patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. Inheritance is autosomal recessive.
      SIMILARITY: SwissProt: P28329 ## Belongs to the carnitine/choline acetyltransferase family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material dry at -20°C or -70°C for up to 6 months after date of receipt. After reconstitution, maintain at -20°C in undiluted aliquots for up to 6 months. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Choline Acetyltransferase Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Choline Acetyltransferase Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) - 24922072492207
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) - 25261982526198
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) - 32164803216480
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) - 33792663379266
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) -28847802884780
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY3043066
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY - 21425932142593
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY -25943302594330
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY -26680862668086
      RABBIT ANTI-CHOLINE ACETYLTRANSFERASE (ChAT) POLYCLONAL ANTIBODY -26697162669716

      References

      Reference overviewApplicationSpeciesPub Med ID
      Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration.
      Tuinstra, HM; Margul, DJ; Goodman, AG; Boehler, RM; Holland, SJ; Zelivyanskaya, ML; Cummings, BJ; Anderson, AJ; Shea, LD
      Tissue engineering. Part A  20  1027-37  2014

      Show Abstract
      Immunofluorescence24168314 24168314
      Axotomy induced changes in neuronal plasticity of sympathetic chain ganglia (SChG) neurons supplying descending colon in the pig.
      Cezary Skobowiat,Jaroslaw Calka,Mariusz Majewski
      Experimental and molecular pathology  90  2011

      Show Abstract
      21110956 21110956
      Chronic electrical neuronal stimulation increases cardiac parasympathetic tone by eliciting neurotrophic effects.
      Rana, OR; Saygili, E; Gemein, C; Zink, MD; Buhr, A; Saygili, E; Mischke, K; Nolte, KW; Weis, J; Weber, C; Marx, N; Schauerte, P
      Circulation research  108  1209-19  2011

      Show Abstract
      21441135 21441135
      Distribution pattern and chemical coding of neurons of the sympathetic chain ganglia supplying the descending colon in the pig.
      Cezary Skobowiat,Jarosław Calka,Krzysztof Wasowicz,Mariusz Majewski
      Acta veterinaria Hungarica  58  2010

      Show Abstract
      20460218 20460218
      Acetylcholine as an age-dependent non-neuronal source in the heart.
      Obaida R Rana,Patrick Schauerte,Rahel Kluttig,Jörg W Schröder,Rory R Koenen,Christian Weber,Kay W Nolte,Joachim Weis,Rainer Hoffmann,Nikolaus Marx,Erol Saygili
      Autonomic neuroscience : basic & clinical  156  2010

      Show Abstract
      20510655 20510655
      Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats.
      Gu, W; Gu, C; Jiang, W; Wester, P
      Stem cell research  4  148-54  2010

      Show Abstract
      20089468 20089468
      Persistent west nile virus associated with a neurological sequela in hamsters identified by motor unit number estimation.
      Venkatraman Siddharthan, Hong Wang, Neil E Motter, Jeffery O Hall, Robert D Skinner, Ramona T Skirpstunas, John D Morrey, Venkatraman Siddharthan, Hong Wang, Neil E Motter, Jeffery O Hall, Robert D Skinner, Ramona T Skirpstunas, John D Morrey, Venkatraman Siddharthan, Hong Wang, Neil E Motter, Jeffery O Hall, Robert D Skinner, Ramona T Skirpstunas, John D Morrey
      Journal of virology  83  4251-61  2009

      Show Abstract Full Text Article
      19224990 19224990
      Distribution of cholinergic cells in guinea pig brainstem.
      S D Motts, A S Slusarczyk, C S Sowick, B R Schofield, S D Motts, A S Slusarczyk, C S Sowick, B R Schofield
      Neuroscience  154  186-95  2008

      Show Abstract Full Text Article
      18222049 18222049
      CXCR4 receptors in the dorsal medulla: implications for autonomic dysfunction.
      Hermann, GE; Van Meter, MJ; Rogers, RC
      The European journal of neuroscience  27  855-64  2008

      Show Abstract
      18333961 18333961
      West Nile virus-induced acute flaccid paralysis is prevented by monoclonal antibody treatment when administered after infection of spinal cord neurons.
      Morrey, JD; Siddharthan, V; Wang, H; Hall, JO; Skirpstunas, RT; Olsen, AL; Nordstrom, JL; Koenig, S; Johnson, S; Diamond, MS
      Journal of neurovirology  14  152-63  2008

      Show Abstract
      Immunohistochemistry18444087 18444087

      Related Products & Applications

      Related Products

      Alternative Format

      Catalog Number Description  
      AB5042P Anti-Choline Acetyltransferase Antibody Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies