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05-532 Anti-CaM Kinase II Antibody, α subunit, clone 6G9

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05-532
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, RIHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-532
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-CaM Kinase II Antibody, α subunit, clone 6G9
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% azide before the addition of glycerol to 30%
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CaM Kinase II Antibody, α subunit, clone 6G9 is validated for use in IH, WB for the detection of CaM Kinase II.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenPartially purified rat CaM Kinase II, α-subunit
      Cloneclone 6G9
      HostMouse
      Specificityα subunit of CaM Kinase II
      IsotypeIgG1
      Species Reactivity
      • Bovine
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
      Gene Symbol
      • CAMK2A
      • KIAA0968
      • CAMKA
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
      SIZE: 478 amino acids; 54030 Da
      SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
      SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
      SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
      Molecular Weight50kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on bovine brain cytosol or rat brain microsome preparations
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      05-532 04053252674716

      Documentation

      Anti-CaM Kinase II Antibody, α subunit, clone 6G9 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CaM Kinase II Antibody, α subunit, clone 6G9 Certificates of Analysis

      TitleLot Number
      Anti-CaM Kinase II, #945; subunit, clone 6G9 (mouse monoclonal IgG1) - 2116606 2116606
      Anti-CaM Kinase II, #945; subunit, clone 6G9 (mouse monoclonal IgG1) - 2150161 2150161
      Anti-CaM Kinase II, a subunit, clone 6G9 (mouse monoclonal IgG1) 2918901
      Anti-CaM Kinase II, a subunit, clone 6G9 (mouse monoclonal IgG1) - 2225266 2225266
      Anti-CaM Kinase II, a subunit, clone 6G9 (mouse monoclonal IgG1) - 2343574 2343574
      Anti-CaM Kinase II, a subunit, clone 6G9 - 1982606 1982606
      Anti-CaM Kinase II, a subunit, clone 6G9 - 2032283 2032283
      Anti-CaM Kinase II, a subunit, clone 6G9 - 2044185 2044185
      Anti-CaM Kinase II, a subunit, clone 6G9 - JBC1863416 JBC1863416
      Anti-CaM Kinase II, alpha; subunit, clone 6G9 - 19483 19483

      References

      Reference overviewApplicationPub Med ID
      Differential regulation of apical-basolateral dendrite outgrowth by activity in hippocampal neurons.
      Yuan, Y; Seong, E; Yuan, L; Singh, D; Arikkath, J
      Frontiers in cellular neuroscience  9  314  2015

      Show Abstract
      26321915 26321915
      Adeno-associated viral serotypes produce differing titers and differentially transduce neurons within the rat basal and lateral amygdala.
      Holehonnur, R; Luong, JA; Chaturvedi, D; Ho, A; Lella, SK; Hosek, MP; Ploski, JE
      BMC neuroscience  15  28  2014

      Show Abstract
      24533621 24533621
      Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.
      Ruocco, LA; Treno, C; Gironi Carnevale, UA; Arra, C; Boatto, G; Nieddu, M; Pagano, C; Illiano, P; Barbato, F; Tino, A; Carboni, E; Laviola, G; Lacivita, E; Leopoldo, M; Adriani, W; Sadile, AG
      PloS one  9  e83003  2014

      Show Abstract
      Western Blotting24709857 24709857
      Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine.
      Musazzi, L; Seguini, M; Mallei, A; Treccani, G; Pelizzari, M; Tornese, P; Racagni, G; Tardito, D
      BMC neuroscience  15  119  2014

      Show Abstract
      Western Blotting25332063 25332063
      Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell.
      Robison, AJ; Vialou, V; Mazei-Robison, M; Feng, J; Kourrich, S; Collins, M; Wee, S; Koob, G; Turecki, G; Neve, R; Thomas, M; Nestler, EJ
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  4295-307  2013

      Show Abstract
      23467346 23467346
      Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins.
      Bayés, A; Collins, MO; Croning, MD; van de Lagemaat, LN; Choudhary, JS; Grant, SG
      PloS one  7  e46683  2012

      Show Abstract
      23071613 23071613
      Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation.
      Chen, DY; Bambah-Mukku, D; Pollonini, G; Alberini, CM
      Nature neuroscience  15  1707-14  2012

      Show Abstract
      23160045 23160045
      Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training.
      Fornari, RV; Wichmann, R; Atucha, E; Desprez, T; Eggens-Meijer, E; Roozendaal, B
      Frontiers in behavioral neuroscience  6  10  2012

      Show Abstract
      22435055 22435055
      Lmo4 in the basolateral complex of the amygdala modulates fear learning.
      Maiya, R; Kharazia, V; Lasek, AW; Heberlein, U
      PloS one  7  e34559  2012

      Show Abstract
      22509321 22509321
      Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.
      Ting, AK; Chen, Y; Wen, L; Yin, DM; Shen, C; Tao, Y; Liu, X; Xiong, WC; Mei, L
      The Journal of neuroscience : the official journal of the Society for Neuroscience  31  15-25  2011

      Show Abstract
      21209185 21209185

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies