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AB4250 Anti-CXC Chemokine Receptor 3 Antibody, CT domain

AB4250
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB4250
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CXC Chemokine Receptor 3 Antibody, CT domain
      Alternate Names
      • CXCR3
      Background InformationCXCR3, a chemokine receptor, is highly similar to the interleukin 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al., 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atherosclerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.
      References
      Product Information
      FormatAffinity Purified
      PresentationPeptide-affinity purified immunoglobulin. Liquid in PBS with less than 0.1% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-CXC Chemokine Receptor 3 Antibody, C-terminal domain detects level of CXC Chemokine Receptor 3 & has been published & validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry (formalin-fixed paraffin-embedded tissues)

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a sequence within the C-terminal domain of human CXCR3. The immunogen has 82% homology with rat and mouse.
      EpitopeC-terminal domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human CXCR3. The specificity of this antibody has been evaluated by IHC staining of human tonsil.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Historically, CD183 is the third CXC chemokine receptor discovered and, therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. Therefore, CD183 is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases.
      Gene Symbol
      • CXCR3
      • CD182
      • CXC-R3
      • IP10-R
      • IP10
      • Mig-R
      • CD183
      • CKR-L2
      • CMKAR3
      • GPR9
      • CXCR-3
      • MigR
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49682 # Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 2 may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11.
      SIZE: 368 amino acids; 40660 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
      SIMILARITY: SwissProt: P49682 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 12 months from date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CXC Chemokine Receptor 3 Antibody, CT domain SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CXC Chemokine Receptor 3 Antibody, CT domain Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN CXC CHEMOKINE RECEPTOR 3 - 3013581 3013581
      RABBIT ANTI-HUMAN CXC CHEMOKINE RECEPTOR 3 POLYCLONAL ANTIBODY 2967779
      RABBIT ANTI-HUMAN CXC CHEMOKINE RECEPTOR 3 POLYCLONAL ANTIBODY - 2061585 2061585
      RABBIT ANTI-HUMAN CXC CHEMOKINE RECEPTOR 3 POLYCLONAL ANTIBODY - 2344398 2344398
      RABBIT ANTI-HUMAN CXC CHEMOKINE RECEPTOR 3, POLYCLONAL ANTIBODY 2838493

      References

      Reference overviewPub Med ID
      An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.
      Lasagni, Laura, et al.
      J. Exp. Med., 197: 1537-49 (2003)  2003

      Show Abstract
      12782716 12782716
      Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
      Jones, P F, et al.
      Proc. Natl. Acad. Sci. U.S.A., 88: 4171-5 (1991)  1991

      Show Abstract
      1851997 1851997