123871 Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem

123871
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123871-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable and blood-brain barrier permeant HA14-1 (Cat. No. 371971) analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO model (40 mg/kg, i.p.) in vivo.
      Catalogue Number123871
      Brand Family Calbiochem®
      SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
      References
      ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
      Product Information
      CAS number305834-79-1
      FormOff-white solid
      Hill FormulaC₁₇H₁₇ClN₂O₅
      Chemical formulaC₁₇H₁₇ClN₂O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPleckstrin homology (PH) domain of Akt
      Purity≥98% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Akt Activator II, SC79 - CAS 305834-79-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      123871

      References

      Reference overview
      Jo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-November-2013 JSW
      SynonymsEthyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
      DescriptionA cell-permeable and blood-brain barrier permeant bromo-to-chloro substituted HA14-1 (Cat. No. 371971) analog that renders Akt in a conformation susceptible to phosphorylation by upstream kinases via specific interaction with Akt pleckstrin homology (PH) domain PtdIns(3,4,5)P3- (PIP3) binding pocket. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473) in a time- and dose-dependent manner (2 to 4 µg/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4 µg/ml) in vitro and in a murine MCAO (middle cerebral artery occlusion) model (40 mg/kg, i.p.) in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number305834-79-1
      Chemical formulaC₁₇H₁₇ClN₂O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC (sum of two isomers)
      SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and immediately freeze (-70°C). Stock solutions are stable for up to 2 weeks at -70°C.
      Toxicity Standard Handling
      ReferencesJo. H., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 10581.