505018 ATPA - CAS 140158-50-5 - Calbiochem

505018
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Key Specifications Table

Empirical FormulaCAS #
C₁₀H₁₆N₂O₄ 140158-50-5

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      Glass bottle 1 mg
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      Description
      OverviewA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38 µM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and ∞ µM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22 µM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity.
      Catalogue Number505018
      Brand Family Calbiochem®
      Synonyms2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA
      Application Data
      References
      ReferencesLunn, ML., 2003. J. Med. Chem. 46, 872.
      Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
      Clarke, V., et al. 2002. Neuropharm. 42, 889.
      Kristensen, W., et al. 2001. Brain Res. 917, 21.
      Standley, S., et al. 1998. Exp. Neurol. 152, 208.
      Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
      Clarke, et al. 1997. Nature. 389, 599.
      Product Information
      CAS number140158-50-5
      FormWhite powder
      Hill FormulaC₁₀H₁₆N₂O₄
      Chemical formulaC₁₀H₁₆N₂O₄
      Applications
      Biological Information
      Primary TargetGluK1
      Purity≥97% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ATPA - CAS 140158-50-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Lunn, ML., 2003. J. Med. Chem. 46, 872.
      Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
      Clarke, V., et al. 2002. Neuropharm. 42, 889.
      Kristensen, W., et al. 2001. Brain Res. 917, 21.
      Standley, S., et al. 1998. Exp. Neurol. 152, 208.
      Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
      Clarke, et al. 1997. Nature. 389, 599.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, (RS)-2-Amino-3-(3-hydroxy-5-tert-bu-tylisoxazol-4-yl)propanoic acid, Kainate Receptor Agonist, ATPA, (R,S)-ATPA
      Application Data
      DescriptionA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.33, 0.80, and 0.38 µM for GluK1, GluK1/K2, and GluK1/K5, respectively) over GluK2-containing subtypes (EC50 = 106 and ∞ µM for GluK2/K5 and GluK2 respectively). Weakly interacts with AMPA receptors (EC50 = 7.6, 7.9 and 22 µM for GluA4, GluA3, and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in synaptic transmission and plasticity.
      FormWhite powder
      CAS number140158-50-5
      Chemical formulaC₁₀H₁₆N₂O₄
      Purity≥97% by TLC
      SolubilityAqueous basic solutions
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLunn, ML., 2003. J. Med. Chem. 46, 872.
      Frydenvang, K., et al. 2002. Struct. Chem. 13, 479.
      Clarke, V., et al. 2002. Neuropharm. 42, 889.
      Kristensen, W., et al. 2001. Brain Res. 917, 21.
      Standley, S., et al. 1998. Exp. Neurol. 152, 208.
      Curry, K., et al. 1998. Can. J. Physiol. & Pharmacol. 76, 690.
      Clarke, et al. 1997. Nature. 389, 599.