531621 APT2 Inhibitor, Cpd1 - Calbiochem

A cell permeable, selective, and reversisble inhibitor of lysophopholipase 2 (LYPLA2; IC₅₀ = 510 nM, Ki = 230 nM). Does not affect LYPLA1.

APT2 Inhibitor, Cpd1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Lysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor

Primary Target: APT2
531621
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₃H₂₂N₂O₄S₂

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      5.31621.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA cell permeable acetylpiperazine derivative that acts as a selective and reversible inhibitor of lysophopholipase 2 (LYPLA2; IC50 = 510 nM, Ki = 230 nM) without affecting the activity of LYPLA1 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA2 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number531621
          Brand Family Calbiochem®
          SynonymsLysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor
          References
          ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
          Product Information
          FormPale orange powder
          Hill FormulaC₂₃H₂₂N₂O₄S₂
          Chemical formulaC₂₃H₂₂N₂O₄S₂
          ReversibleY
          Applications
          Biological Information
          Primary TargetAPT2
          Primary Target IC<sub>50</sub>510 nM, Ki
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          APT2 Inhibitor, Cpd1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Adibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-March-2015 JSW
          SynonymsLysophosphilipase 2 Inhibitor, LYPLA2 Inhibitor
          DescriptionA cell permeable acetylpiperazine derivative that acts as a selective and reversible inhibitor of lysophopholipase 2 (LYPLA2; IC50 = 510 nM, Ki = 230 nM) without affecting the activity of LYPLA1 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA2 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
          FormPale orange powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₃H₂₂N₂O₄S₂
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesAdibekian, A., et al. 2012. J. Am. Chem. Soc. 134, 10345.