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Description
Overview
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number
531620
Brand Family
Calbiochem®
Synonyms
LYPLA1 Inhibitor, Lysophospholipase Inhibitor
References
References
Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.
Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
09-December-2014
Synonyms
LYPLA1 Inhibitor, Lysophospholipase Inhibitor
Description
A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC50 = 840 nM, Ki = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₁₈H₁₇ClF₃N₃O₃
Purity
≥98% by HPLC
Solubility
DMSO (50 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.