171260 AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

171260
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₄H₂₅N₅O 866405-64-3

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171260-10MG
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      171260-1MG
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          171260-5MG
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              Description
              OverviewA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
              Catalogue Number171260
              Brand Family Calbiochem®
              Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
              References
              ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
              Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
              Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
              Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
              Inoki, K., et al. 2003. Cell 115, 577.
              Fryer, L.G., 2002. FEBS Lett. 531, 189.
              Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
              Product Information
              CAS number866405-64-3
              ATP CompetitiveY
              FormLight yellow solid
              Hill FormulaC₂₄H₂₅N₅O
              Chemical formulaC₂₄H₂₅N₅O
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetAMPK
              Primary Target IC<sub>50</sub>25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
              Primary Target K<sub>i</sub>EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Certificates of Analysis

              TitleLot Number
              171260

              References

              Reference overview
              Hao, J., et al. 2010. ACS Chem.Biol. 5, 245.
              Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
              Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
              Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
              Inoki, K., et al. 2003. Cell 115, 577.
              Fryer, L.G., 2002. FEBS Lett. 531, 189.
              Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision22-March-2012 JSW
              Synonyms6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I
              DescriptionA cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Also available as a 10 mM solution in DMSO (Cat. No. 171261).
              FormLight yellow solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number866405-64-3
              Chemical formulaC₂₄H₂₅N₅O
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (4 mg/ml), 2% HCl (10 mg/ml), 2% Acetic Acid (10 mg/ml), or Methanol (3 mg/ml)
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesHao, J., et al. 2010. ACS Chem.Biol. 5, 245.
              Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
              Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
              Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
              Inoki, K., et al. 2003. Cell 115, 577.
              Fryer, L.G., 2002. FEBS Lett. 531, 189.
              Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.