533642 AMP Deaminase Inhibitor, Cpd3 - Calbiochem

533642
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₄H₂₁N₃O₂

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.33642.0001
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50 = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.
      Catalogue Number533642
      Brand Family Calbiochem®
      Synonyms(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMP Deaminase Inhibitor, AMPD Inhibitor
      References
      ReferencesAdmyre, T., et al. 2014. Chem. Biol. 21, 1486.
      Product Information
      FormWhite solid
      Hill FormulaC₂₄H₂₁N₃O₂
      Chemical formulaC₂₄H₂₁N₃O₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>38 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMP Deaminase Inhibitor, Cpd3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Admyre, T., et al. 2014. Chem. Biol. 21, 1486.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-September-2017 JSW
      Synonyms(S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMP Deaminase Inhibitor, AMPD Inhibitor
      DescriptionA cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC50 = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₁N₃O₂
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAdmyre, T., et al. 2014. Chem. Biol. 21, 1486.