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504745 AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem

504745
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Key Specifications Table

Empirical FormulaCAS #
C₂₈H₂₈N₂ • 2HCl 97075-46-2

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      Description
      OverviewA potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
      Catalogue Number504745
      Brand Family Calbiochem®
      SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
      References
      ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
      Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
      Flor, X., et al. 2005. Neuropharmacology 49, 244.
      Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
      Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
      Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
      Product Information
      CAS number97075-46-2
      FormWhite solid
      Hill FormulaC₂₈H₂₈N₂ • 2HCl
      Chemical formulaC₂₈H₂₈N₂ • 2HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₇ receptors
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
      Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
      Flor, X., et al. 2005. Neuropharmacology 49, 244.
      Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
      Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
      Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      SynonymsN,N'-Dibenzhydrylethane-1,2-diamine dihydrochloride
      DescriptionA potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinsons disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
      FormWhite solid
      CAS number97075-46-2
      Chemical formulaC₂₈H₂₈N₂ • 2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
      Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
      Flor, X., et al. 2005. Neuropharmacology 49, 244.
      Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
      Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
      Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.