531726 ALDH1A1, A37 - Calbiochem

531726
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₂₅N₃O₃S₂

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; Ki = 300 nM; IC50 = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (> 100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531726
      Brand Family Calbiochem®
      Synonymsthieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37
      References
      ReferencesCondello, S., et al. 2014. Oncogene. 33, in press.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₁H₂₅N₃O₃S₂
      Chemical formulaC₂₁H₂₅N₃O₃S₂
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetALDH1A1
      Primary Target IC<sub>50</sub>4.6 µM
      Primary Target K<sub>i</sub>300 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ALDH1A1, A37 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Condello, S., et al. 2014. Oncogene. 33, in press.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2015 JSW
      Synonymsthieno[3,2-d]pyrimidin-2-yl]thio}acetate, Acetaldehyde Dehydrogenase 1A1 inhibitor, A37
      DescriptionA cell permeable benzothieno[3,2-d]pyrimidone derivative that acts as a selective, substrate competitive inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1; Ki = 300 nM; IC50 = 4.6 µM) in ovarian cancer spheroids. Does not affect the activity of other related orthologs, including ALDH1A2, ALDH1A3, ALDH2 and ALDH3A1 even at higher concentrations (> 100 µM). Enhances sensitization of IGROV1 ovarian carcinoma cells to cisplatin. Disrupts spheroid formation and reduces viability of ovarian cancer cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₁H₂₅N₃O₃S₂
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCondello, S., et al. 2014. Oncogene. 33, in press.