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508505 A-803467 - CAS 944261-79-4 - Calbiochem

A voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC₅₀) = 140 nM).

A-803467 - CAS 944261-79-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467

Primary Target: Nav1.8
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
944261-79-4C₁₉H₁₆ClNO₄

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      Description
      OverviewA voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
      Catalogue Number508505
      Brand Family Calbiochem®
      SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
      References
      ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
      Product Information
      CAS number944261-79-4
      FormWhite solid
      Hill FormulaC₁₉H₁₆ClNO₄
      Chemical formulaC₁₉H₁₆ClNO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNav1.8
      Primary Target IC<sub>50</sub>8 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      5.08505.00014055977261981

      Documentation

      A-803467 - CAS 944261-79-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2014 JSW
      SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
      DescriptionA voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
      FormWhite solid
      CAS number944261-79-4
      Chemical formulaC₁₉H₁₆ClNO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM) or EtOH (25 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.