565792 γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

565792
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₃₀H₃₉N₇O

Pricing & Availability

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565792-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
      Catalogue Number565792
      Brand Family Calbiochem®
      References
      ReferencesRivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
      Product Information
      FormBeige solid
      Hill FormulaC₃₀H₃₉N₇O
      Chemical formulaC₃₀H₃₉N₇O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem Certificates of Analysis

      TitleLot Number
      565792

      References

      Reference overview
      Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-June-2011 JSW
      DescriptionA cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
      FormBeige solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₃₉N₇O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesRivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.