On-Demand Webinar

Reducing Costs in Solid Dose Formulations

Duration: 1 Hour
Speaker: Dr. Leo Ohrem, Portfolio Development Manager, MilliporeSigma

Abstract: Reducing costs is a constant concern in pharmaceutical production. However, choosing the cheapest raw materials may not be the optimal choice with regards to the overall cost of ownership. In this webinar, we highlight how the proper selection of functional excipients can help reduce overall costs. The webinar discusses stability issues arising from excipient byproducts, which can lead to prolonged development time, as well as mechanical stability of the finished product.

Mechanical stability becomes relevant in large scale operations due to the fact that subsequent handling of a robust tablet leads to less scrap rate in the final quality check. Additionally, excipients with high functionality may enable the formulator to reduce the number of single excipients needed in a formulation. This minimizes time for development and registration as well as risk for further API interaction and reduces costs. Most importantly is to achieve possibilities for direct compression as a process in competition with wet granulation.

This webinar presentation shows how to overcome the most prevalent technical limitations for direct compression including content uniformity, compressibility and flow.

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