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Purospher® STAR RP-8 Endcapped (5 µm) HPLC Columns

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Chromolith® RP-18 Endcapped Monolithic HPLC ColumnsMilliporeSigma offers a broad range of HPLC columns that are fully compliant with USP (United States Pharmacopoeia) specifications. L7 USP columns are described as octyl silane (C8), chemically linked to porous silica particles, 1.5 to 10 µm in diameter. Our high-quality L7 USP columns include: Purospher® STAR RP-8 endcapped (5 µm).

Optimized for Polar Compounds

Purospher® STAR RP-8 endcapped HPLC columns are less hydrophobic than Purospher® STAR RP-18 endcapped, hence analytes typically elute faster on the C8 phase. This results in enhanced selectivity for positional isomers, and excellent peak symmetry for strongly basic and polar compounds.

Purospher® STAR RP-8 endcapped is based on high-purity silica with virtually perfect surface coverage. This ensures the highest efficiency in terms of the number of theoretical plates, and outstanding stability from pH 1.5 to 10.5. With trace metal levels below 5 ppm in total, Purospher® STAR RP-8 endcapped columns deliver highly symmetrical peaks for acidic, basic and chelating compounds. The columns are available in a large selection of hardware formats to suit various requirements.

Features and Benefits

  • Classified as L7 USP column
  • Enhanced selectivity for positional isomers
  • Excellent peak symmetry for strongly basic and polar drugs
  • Exceptional stability from pH 1.5 to 10.5
  • Highest efficiency in terms of number of theoretical plates

Application Examples

Separation of caffeine and deerivatives 

Separation of antidepressants

Specifications of Purospher® STAR RP-8 Endcapped

Sorbent characteristics High-purity C8-modified silica gel with endcapping
Metal content Na, Ca, Mg, Al: 1 ppm; Fe: 3 ppm
Particle shape Spherical
Particle size 5 μm
Pore size 120 Å
Pore volume 1.1 mL/g
Surface area 330 m2/g
Carbon load 11,2 % C
Efficiency 5 μm: > 80.000 N/m
pH range pH 1.5 - 10.5
Shipping eluent Acetonitrile/Water
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