500501 Sigma-AldrichiPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 300586-90-7 | C₁₄H₁₁N₃O |
| Description | |
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| Overview | A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 µM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500501 |
| Brand Family | Calbiochem® |
| Synonyms | N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1 |
| References | |
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| References | Li, W., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 20853. |
| Product Information | |
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| CAS number | 300586-90-7 |
| Form | Off-white solid |
| Hill Formula | C₁₄H₁₁N₃O |
| Chemical formula | C₁₄H₁₁N₃O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Identification Number | |
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| Catalog Number | GTIN |
| 500501 | |
Documentation
iPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem SDS
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References
| Reference overview |
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| Li, W., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 20853. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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