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504777 Yohimbine Hydrochloride - CAS 65-19-0 - Calbiochem

Yohimbine Hydrochloride is a potent antagonist for α₂-adrenoceptors, α2B and α2C receptors respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α₂-Adrenoceptor Antagonist, Yohimbine Hydrochloride

Primary Target: →₂-adrenoceptor
504777
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₂₆N₂O₃ • HCl

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      Description
      OverviewA potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
      Catalogue Number504777
      Brand Family Calbiochem®
      Synonyms17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α₂-Adrenoceptor Antagonist, Yohimbine Hydrochloride
      References
      ReferencesCalu, D., et al. 2013. J. Neurosci. 33, 214.
      Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
      Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
      Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.
      Product Information
      CAS number65-19-0
      FormPale yellow solid
      Hill FormulaC₂₁H₂₆N₂O₃ • HCl
      Chemical formulaC₂₁H₂₆N₂O₃ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target→₂-adrenoceptor
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Yohimbine Hydrochloride - CAS 65-19-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Calu, D., et al. 2013. J. Neurosci. 33, 214.
      Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
      Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
      Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α₂-Adrenoceptor Antagonist, Yohimbine Hydrochloride
      DescriptionA potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
      FormPale yellow solid
      CAS number65-19-0
      Chemical formulaC₂₁H₂₆N₂O₃ • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mM). Slight warming is required for complete solubilization.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesCalu, D., et al. 2013. J. Neurosci. 33, 214.
      Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol. 325, 136.
      Goldberg, K., et al. 1987. Pharmacol. Rev. 35, 143.
      Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther. 303, 979.