682160 Xestospongin C, Xestospongia sp. - Calbiochem

682160
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₈H₅₀N₂O₂

Pricing & Availability

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682160-10UG
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      Plastic ampoule 10 μg
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      Description
      OverviewAn oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.
      Catalogue Number682160
      Brand Family Calbiochem®
      SynonymsXeC
      References
      ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
      Gafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
      Product Information
      ATP CompetitiveN
      FormWhite to off-white film
      Hill FormulaC₂₈H₅₀N₂O₂
      Chemical formulaC₂₈H₅₀N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationXestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).
      Biological Information
      Primary TargetIP3-mediated Ca2+ release
      Primary Target IC<sub>50</sub>358 nM in blocking IP3-mediated Ca2+ release
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Xestospongin C, Xestospongia sp. - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Xestospongin C, Xestospongia sp. - Calbiochem Certificates of Analysis

      TitleLot Number
      682160

      References

      Reference overview
      Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
      Gafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.

      Citations

      Title
    • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
    • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-January-2019 JSW
      SynonymsXeC
      DescriptionA macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the ER stores in a reversible manner.
      FormWhite to off-white film
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₅₀N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml). Sonication may be required to achieve complete solubilization.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
      Gafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
      Citation
    • M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.
    • Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.
    • Related Products & Applications

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators