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681667 Wnt Agonist II, SKL2001 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₄N₄O₃

Products

Catalog NumberPackaging Qty/Pack
681667-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable imidazolyl-isoxazolamide that upregulates β-catenin-regulated transcription (CRT; 10 - 40 µM) by disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
Catalogue Number681667
Brand Family Calbiochem®
Synonyms5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
References
ReferencesGwak, J., et al. 2012. Cell Res. 22, 237.
Product Information
FormPinkish red solid
Hill FormulaC₁₄H₁₄N₄O₃
Chemical formulaC₁₄H₁₄N₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationWnt Agonist II, SKL2001, CAS 909089-13-0, upregulates β-catenin-regulated transcription by disrupting β-catenin & Axin interaction. Prevents β-catenin phosphorylation and proteasomal degradation.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
681667-25MG 04055977260250

Documentation

Wnt Agonist II, SKL2001 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Wnt Agonist II, SKL2001 - Calbiochem Certificates of Analysis

TitleLot Number
681667

References

Reference overview
Gwak, J., et al. 2012. Cell Res. 22, 237.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-October-2012 JSW
Synonyms5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
DescriptionA cell-permeable imidazolyl-isoxazolamide compound that upregulates β-catenin-regulated transcription (CRT; Effective conc. 10 - 40 µM) by blocking/disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Wnt pathway activation by SKL2001 is shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
FormPinkish red solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₁₄N₄O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml; clear, red solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGwak, J., et al. 2012. Cell Res. 22, 237.