681685 Sigma-AldrichWP1130 - Calbiochem
A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.
More>> A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Less<<WP1130 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Degrasyn
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Overview
Replacement Information |
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Key Specifications Table
Empirical Formula |
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C₁₉H₁₈BrN₃O |
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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681685-10MG |
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Glass bottle | 10 mg |
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Description | |
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Overview | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-κB activities (IC50 < 1 µM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2 µM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5 µM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 (Cat. No. 573097) in xenograft mouse models of CML and melanoma. |
Catalogue Number | 681685 |
Brand Family | Calbiochem® |
Synonyms | Degrasyn |
Product Information | |
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Form | Light yellow solid |
Hill Formula | C₁₉H₁₈BrN₃O |
Chemical formula | C₁₉H₁₈BrN₃O |
Structure formula Image | |
Quality Level | MQ100 |
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Biological Information | |
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Purity | ≥97% by HPLC |
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Safety Information according to GHS |
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Safety Information |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Documentation
WP1130 - Calbiochem SDS
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WP1130 - Calbiochem Certificates of Analysis
Title | Lot Number |
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681685 |
References
Reference overview |
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Kapuria, V., et al. 2010. Cancer Res. 70, 9265. Pham, L.V., et al. 2010. Mol. Cancer Ther. 9, 2026. Bartholomeusz, G.A, et al. 2007. Cancer Res. 67, 3912. Bartholomeusz, G.A, et al. 2007. Blood 109, 3470. |