GF175 WNT-1, Human Recombinant

GF175
10 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSourcePurity
      Cult E. coli. Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
      Description
      Catalogue NumberGF175
      DescriptionWNT-1, Human Recombinant
      Alternate Names
      • WNT1
      • Proto-oncogene Wnt-1
      • Proto-oncogene Int-1 homolog
      Background InformationWnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.
      References
      Product Information
      PresentationProduct is filtered through a 0.2 micron filter before lyophilization. Product is presented in .
      Quality LevelMQ100
      Applications
      Key Applications
      • Stem Cell Culture
      Biological Information
      PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
      SourceE. coli.
      Cross ReactivityMouse
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: The ED50 was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED50 for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      WNT-1, Human Recombinant SDS

      Title

      Safety Data Sheet (SDS) 

      WNT-1, Human Recombinant Certificates of Analysis

      TitleLot Number
      Recombinant Human WNT- 1 Recombinant Protein3085049
      Recombinant Human WNT-1 - 21460332146033
      Recombinant Human WNT-1 - 23735132373513
      Recombinant Human -28019602801960
      Recombinant Human -28172662817266
      Recombinant Human WNT- 1 - 25120522512052
      Recombinant Human WNT- 1 - 33979913397991
      Recombinant Human WNT- 1 Recombinant Protein2961180
      Recombinant Human WNT- 1 Recombinant Protein3093143
      Recombinant Human WNT-1 - 23000232300023

      Related Products & Applications

      Product Families

      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors