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505989 Vigabatrin - CAS 68506-86-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
68506-86-5C₆H₁₁NO₂

Products

Catalog NumberPackaging Qty/Pack
5.05989.0001 Glass bottle 10 mg
Description
OverviewA selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9 mM)
Catalogue Number505989
Brand Family Calbiochem®
SynonymsGABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril, 4-Amino-5-hexenoic acid
References
ReferencesAbbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.
Product Information
CAS number68506-86-5
FormWhite solid
Hill FormulaC₆H₁₁NO₂
Chemical formulaC₆H₁₁NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGABA Transaminase
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.05989.0001 04055977262612

Documentation

Vigabatrin - CAS 68506-86-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Abbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2013 JSW
SynonymsGABA Transaminase Inhibitor, Vigabatrin, γ-Vinyl-GABA, Sabril, 4-Amino-5-hexenoic acid
DescriptionA selective, irreversible inhibitor of GABA transaminase with antiepileptic properties. Covalently binds to the active site of GABA tansaminase to inactivate it in a dose-dependent manner and increases extracellular GABA levels in the brain. Rapidly absorbed following oral administration and is shown to inhibit [3H]GABA uptake across the apical membrane of Caco-2 cell monolayers in a concentration-dependent manner (IC50 = 2.9 mM)
FormWhite solid
CAS number68506-86-5
Chemical formulaC₆H₁₁NO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesAbbot, E.L., et al. 2006. Br. J. Pharmacol. 147, 298.
Schmid, L., et al. 1996. J. Pharmacol. Exp. Therap. 276, 977.