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504396 VU0155041, Sodium Salt - Calbiochem

VU0155041, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt

504396
  
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₄Cl₂NNaO₃
Description
OverviewA highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7 µM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventricularlly (icv).
Catalogue Number504396
Brand Family Calbiochem®
Synonymscis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
References
ReferencesNiswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.
Product Information
FormWhite solid
Hill FormulaC₁₄H₁₄Cl₂NNaO₃
Chemical formulaC₁₄H₁₄Cl₂NNaO₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
504396

Documentation

References

Reference overview
Niswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
Synonymscis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
DescriptionA highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7 µM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventricularlly (icv).
FormWhite solid
Chemical formulaC₁₄H₁₄Cl₂NNaO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNiswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.