Product Information
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem Certificates of Analysis

TitleLot Number
648485

References

Reference overview
Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-May-2012 JSW
SynonymsHC-030031
DescriptionA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number349085-38-7
Chemical formulaC₁₈H₂₁N₅O₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml; clear, colorless solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Blockers > Calcium Channel Blockers