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648450 TrkA Inhibitor - CAS 388626-12-8 - Calbiochem

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: TrkA
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648450
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
388626-12-8C₁₅H₁₃N₃O₃S

Products

Catalog NumberPackaging Qty/Pack
648450-1MG Plastic ampoule 1 mg
Description
OverviewAn oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
Catalogue Number648450
Brand Family Calbiochem®
References
ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
Product Information
CAS number388626-12-8
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₃N₃O₃S
Chemical formulaC₁₅H₁₃N₃O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTrkA
Primary Target IC<sub>50</sub>63 nM against TrkA
Purity≥97% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

TrkA Inhibitor - CAS 388626-12-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TrkA Inhibitor - CAS 388626-12-8 - Calbiochem Certificates of Analysis

TitleLot Number
648450

References

Reference overview
Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
DescriptionA potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number388626-12-8
Chemical formulaC₁₅H₁₃N₃O₃S
Structure formulaStructure formula
Purity≥97% by HPLC (sum of two isomers)
SolubilityDMSO (200 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWood, E.R., et al. 2004. Bioorg. Med. Chem. Lett. 14, 953.