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108219 Tris(hydroxymethyl)aminomethane hydrochloride

Overview

Replacement Information

Key Specifications Table

CAS #EC NumberHill FormulaChemical FormulaMolar Mass
1185-53-1 214-684-5 C₄H₁₂ClNO₃ C₄H₁₁NO₃*ClH 157.60 g/mol

Pricing & Availability

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1082191003
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      1082199013
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          Bucket, plastic 12 kg
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          1082199053
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              Description
              Catalogue Number108219
              Synonyms2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride, TRIS hydrochloride, Tris(hydroxymethyl)aminomethane hydrochloride, Trizma® hydrochloride
              DescriptionTris(hydroxymethyl)aminomethane hydrochloride
              References
              Product Information
              CAS number1185-53-1
              EC number214-684-5
              Hill FormulaC₄H₁₂ClNO₃
              Chemical formulaC₄H₁₁NO₃*ClH
              Molar Mass157.60 g/mol
              HS Code2922 19 00
              Structure formula ImageStructure formula Image
              Quality LevelMQ500
              Applications
              Biological Information
              Physicochemical Information
              Density1.28 g/cm3 (20.2 °C)
              Melting Point150.7 °C
              pH value4.2 (100 g/l, H₂O, 20 °C)
              Vapor pressure<1 Pa (50 °C)
              Solubility561 g/l soluble
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Disposal3
              Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +15°C to +25°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Appearance (color)white to almost white
              Appearance (description)crystalline powder
              Assay (Perchloric acid titration, calc. on anhydrous substance)≥ 99.0 %
              Identity (IR-spectrum)conforms
              pH-value (0.5 mol/l, water)3.5 - 5.0
              Melting range147 - 153 °C
              UV-Absorption (230 nm; 10 %; 1 cm; water)≤ 0.1
              UV-Absorption (260 nm; 10 %, 1 cm; water)≤ 0.06
              UV-Absorption (280 nm; 10 %; 1 cm; water)≤ 0.06
              UV-Absorption (300 nm; 10 %; 1 cm; water)≤ 0.02
              UV-Absorption (400 nm; 10 %; 1 cm; water)≤ 0.01
              As (Arsenic)≤ 0.0001 %
              Ca (Calcium)≤ 0.0010 %
              Cd (Cadmium)≤ 0.0001 %
              Cu (Copper)≤ 0.0001 %
              Fe (Iron)≤ 0.0001 %
              Mg (Magnesium)≤ 0.0010 %
              Ni (Nickel)≤ 0.00025 %
              Pb (Lead)≤ 0.0001 %
              Zn (Zinc)≤ 0.0002 %
              Residual solvents (ICHQ3C) of class 2 (Methanol)≤ 3000 ppm
              Residual solvents (ICHQ3C) of class 2 (Nitromethane)≤ 50 ppm
              Residual solvents (ICHQ3C) of class 3 (Ethanol)≤ 5000 ppm
              Residual solvents (ICHQ3C) of class 3 (Ethylmethylketon)≤ 5000 ppm
              Other residual solvents (ICH Q3C)excluded by manufacturing process
              Sulfated ash≤ 0.03
              Loss on Drying (105°C)≤ 0.5
              Water (according to Karl Fischer)≤ 0.5
              Endotoxins< 2.5
              Total aerobic microbial count≤ 10²
              Total yeast and mould count≤ 10²
              Salmonella spp.absent in 10 g
              E.coliabsent in 1 g
              Staphylococcus aureusabsent in 1 g
              Pseudomonas aeruginosaabsent in 1 g
              Candida albicansabsent in 1 g
              Bile tolerante gram negative bacteriaabsent in 1 g
              DNases (Exo- and endonucleases)not detected
              Proteasesnot detected
              RNasesnot detected
              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

              Documentation

              Material Qualification Dossier

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              Quality Management Dossier

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              Operational Excellence Dossier

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              Tris(hydroxymethyl)aminomethane hydrochloride SDS

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              Safety Data Sheet (SDS) 

              Tris(hydroxymethyl)aminomethane hydrochloride Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              1082191003 Plastic bottlePDF Specification Document
              1082199013 Bucket, plasticPDF Specification Document
              1082199053 Plastic drumPDF Specification Document

              Certificates

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