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616373 Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

616373
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Overview

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Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₄ClFN₆ 871307-18-5

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616373-1MG
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      Description
      OverviewA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
      Catalogue Number616373
      Brand Family Calbiochem®
      Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
      References
      ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.
      Product Information
      CAS number871307-18-5
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₁H₁₄ClFN₆
      Chemical formulaC₂₁H₁₄ClFN₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationTpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).
      Biological Information
      Primary TargetTpl2 Kinase
      Primary Target IC<sub>50</sub>50 nM against Tpl2 kinase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      616373

      References

      Reference overview
      Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.

      Brochure

      Title
      MAPK Pathway Poster ( 750 KB )
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 JSW
      Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
      DescriptionA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number871307-18-5
      Chemical formulaC₂₁H₁₄ClFN₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.