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506236 Tiagabine Hydrochloride - CAS 145821-59-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
145821-59-6C₂₀H₂₅NO₂S₂·HCl

Products

Catalog NumberPackaging Qty/Pack
5.06236.0001 Glass bottle 10 mg
Description
OverviewA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
Catalogue Number506236
Brand Family Calbiochem®
SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
References
ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
Hu, Q., et al. 1997. Brain Res. 753,260.
Suzdak, P., et al., 1995. Epilepsia. 36, 612.
Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
Product Information
CAS number145821-59-6
FormOff-white solid
Hill FormulaC₂₀H₂₅NO₂S₂·HCl
Chemical formulaC₂₀H₂₅NO₂S₂·HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGAT-1
Primary Target IC<sub>50</sub>67 nM
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
5.06236.0001 04055977243161

Documentation

Tiagabine Hydrochloride - CAS 145821-59-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Laughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
Hu, Q., et al. 1997. Brain Res. 753,260.
Suzdak, P., et al., 1995. Epilepsia. 36, 612.
Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-September-2013 JSW
SynonymsGABA reuptake inhibitor, Tiagabine, Gabitril, GAT-1 GABA Transporter Inhibitor, Tiagabine
DescriptionA potent uptake inhibitor highly selective for GABA Transport-1 (IC50 = 67 nM in vivo). Clinically used as an anticonvulsant. Often used in studies related to anxiety disorders and neural damages resulted from epileptics.
FormOff-white solid
CAS number145821-59-6
Chemical formulaC₂₀H₂₅NO₂S₂·HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLaughlin, T., et al. 2002. J. Pharmacol. Exp. Ther. 302, 1168.
Hu, Q., et al. 1997. Brain Res. 753,260.
Suzdak, P., et al., 1995. Epilepsia. 36, 612.
Andersen, E., et al., 1993. J. Med. Chem. 36, 1716.