609315 Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem

609315
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₀F₃N₅O₄ 251310-57-3

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609315-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity.
      Catalogue Number609315
      Brand Family Calbiochem®
      SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
      References
      ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
      Product Information
      CAS number251310-57-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₁H₂₀F₃N₅O₄
      Chemical formulaC₂₁H₂₀F₃N₅O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetThyroid Hormone Receptor
      Primary Target IC<sub>50</sub>1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      609315

      References

      Reference overview
      Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2015 JSW
      SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
      DescriptionA cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number251310-57-3
      Chemical formulaC₂₁H₂₀F₃N₅O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.