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609315 Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem

The Thyroid Hormone Receptor Antagonist, 1-850, also referenced under CAS 251310-57-3, controls the biological activity of Thyroid Hormone Receptor. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide

Primary Target: Thyroid Hormone Receptor
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Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
251310-57-3C₂₁H₂₀F₃N₅O₄

Products

Catalog NumberPackaging Qty/Pack
609315-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity.
Catalogue Number609315
Brand Family Calbiochem®
SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
References
ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
Product Information
CAS number251310-57-3
ATP CompetitiveN
FormYellow solid
Hill FormulaC₂₁H₂₀F₃N₅O₄
Chemical formulaC₂₁H₂₀F₃N₅O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetThyroid Hormone Receptor
Primary Target IC<sub>50</sub>1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number GTIN
609315-5MG4055977264555

Documentation

Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Thyroid Hormone Receptor Antagonist, 1-850 - CAS 251310-57-3 - Calbiochem Certificates of Analysis

TitleLot Number
609315

References

Reference overview
Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2015 JSW
SynonymsTR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
DescriptionA cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number251310-57-3
Chemical formulaC₂₁H₂₀F₃N₅O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSchapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7354.