586005 Thapsigargin - CAS 67526-95-8 - Calbiochem

586005
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₄H₅₀O₁₂ 67526-95-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      586005-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
          Catalogue Number586005
          Brand Family Calbiochem®
          References
          ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
          Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
          Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
          Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
          Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
          Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
          Wong, W.L., et al. 1993. Biochem. J. 289, 71.
          Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
          Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
          Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
          Product Information
          CAS number67526-95-8
          ATP CompetitiveN
          FormColorless solid
          Hill FormulaC₃₄H₅₀O₁₂
          Chemical formulaC₃₄H₅₀O₁₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetendoplasmic reticular Ca2+ ATPase
          Primary Target IC<sub>50</sub>4-13 nM against endoplasmic reticular Ca2+-ATPase
          Purity≥97% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38-42

          Irritating to eyes, respiratory system and skin.
          May cause sensitization by inhalation.
          S PhraseS: 36/37/39-26

          Wear suitable protective clothing, gloves and eye/face protection.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Thapsigargin - CAS 67526-95-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Thapsigargin - CAS 67526-95-8 - Calbiochem Certificates of Analysis

          TitleLot Number
          586005

          References

          Reference overview
          Jothi, M., et al. 2013. Mol. Cancer Ther. In press.
          Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
          Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
          Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
          Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
          Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
          Wong, W.L., et al. 1993. Biochem. J. 289, 71.
          Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
          Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
          Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-October-2013 JSW
          DescriptionA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase. Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
          FormColorless solid
          CAS number67526-95-8
          Chemical formulaC₃₄H₅₀O₁₂
          Structure formulaStructure formula
          Purity≥97% by TLC
          SolubilityDMSO (>1 mg/ml) or ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
          Toxicity Irritant
          ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
          Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
          Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
          Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
          Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
          Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
          Wong, W.L., et al. 1993. Biochem. J. 289, 71.
          Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
          Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
          Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
          Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.