GF092 TRAIL Protein, Recombinant human

GF092
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Key ApplicationsSpeciesSourcePurity
      CULT Human E.coli Greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg of (1EU/μg) of TRAIL/Apo2L.
      Description
      Catalogue NumberGF092
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionTRAIL Protein, Recombinant human
      OverviewHuman TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis, is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR transmembrane family of proteins and contain a cytoplasmic "death domain" which activates the cell's apoptotic machinery. GF092 is a 19.6 kDa protein comprising the full-length of the TNF-like extracellular domain of TRAIL.
      Alternate Names
      • Apo2 Ligand
      References
      Product Information
      PresentationSterile filtered, then lyophilized from 0.3 mg/mL in 10mM Sodium Phosphate + 110 mM NaCl.
      Quality LevelMQ100
      Applications
      ApplicationHuman TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg of (1EU/μg) of TRAIL/Apo2L.
      SourceE.coli
      Specific ActivityBIOLOGICAL ACTIVITY: Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/mL.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
      Gene Symbol
      • TNFSF10
      • TL2
      • Apo-2L
      • CD253
      • TRAIL-PEN
      • APO2L
      • TRAIL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P50591 # Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
      COFACTOR: Binds 1 zinc ion per trimer.
      SIZE: 281 amino acids; 32509 Da
      SUBUNIT: Homotrimer.
      SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
      TISSUE SPECIFICITY: Widespread; most predominant in spleen, lung and prostate.
      SIMILARITY: SwissProt: P50591 ## Belongs to the tumor necrosis factor family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized protein may be stored at room temperature for a few weeks, but is best stored at -20°C. After a quick spin, reconstitute in sterile water to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other buffered solutions and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted GF092 should be stored in undiluted aliquots at -20°C for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TRAIL Protein, Recombinant human SDS

      Title

      Safety Data Sheet (SDS) 

      TRAIL Protein, Recombinant human Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN TRAIL/APO2L2901712
      RECOMBINANT HUMAN TRAIL/APO2L2935548
      RECOMBINANT HUMAN TRAIL/APO2L3026746
      RECOMBINANT HUMAN TRAIL/APO2L3015860
      RECOMBINANT HUMAN TRAIL/APO2L3050813
      RECOMBINANT HUMAN TRAIL/APO2L2869282
      RECOMBINANT HUMAN TRAIL/APO2L - 21224252122425
      RECOMBINANT HUMAN TRAIL/APO2L - 23904112390411
      RECOMBINANT HUMAN TRAIL/APO2L - 23245362324536
      RECOMBINANT HUMAN TRAIL/APO2L - 20313252031325

      Data Sheet

      Title
      RECOMBINANT HUMAN TRAIL/APO2L

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors