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654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1049741-03-8C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O

Products

Catalog NumberPackaging Qty/Pack
654256-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
Catalogue Number654256
Brand Family Calbiochem®
Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
References
ReferencesHe, M.M., et al. 2005. Science 310, 1022.
Product Information
CAS number1049741-03-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α
Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalog Number GTIN
654256-5MG 04055977184631

Documentation

TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem Certificates of Analysis

TitleLot Number
654256

References

Reference overview
He, M.M., et al. 2005. Science 310, 1022.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-April-2011 RFH
Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
DescriptionA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1049741-03-8
Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHe, M.M., et al. 2005. Science 310, 1022.